The miRNA target gene data were collected from four well-annotated database
miRTarBase v8.0, TarBase v8.0 and
miRecords .
The data for S.mansoni and S.scrofa are predicted by miRanda by default parameters.
The miRNA to molecule interaction data were collected from SM2miR and
PharmacomiR.
The miRNA to disease interaction data were collected from HMDD 3.2,
miR2Disease and
PhenomiR 2.0 .
The miRNA to epigenetic modifier interaction data were collected from EpimiR.
The miRNA to ncRNA interaction data were collected from starBase v2.0.
The miRNA to TF interaction data were collected from TransmiR v2.0.
The variant annotation data for miRNA, miRNA-binding sites and TF-binding sites were collected from
ADmiRE,
PolymiRTS v3.0
and
SNP2TFBS respectively.
Also we optimize the data by removing the duplicated records and those miRNAs which proved to be wrong in
miRBase v21.
The tissue-specific miRNA annotation data were collected from TSmiR
and IMOTA.
The exosomal miRNA annotation data were collected from ExoCarta.
The miRNA set libraries (Function, Disease, Transcription Factor, Cluster) were collected from TAM 2.0.
Resources for xeno-miRNA data:
Xeno-miRNAs detected from deep sequencing were collected from
Exo-miRExplorer. Xeno-miRNAs manually collected from literature included dietary sources,
parasites exosome-liked vesicles and virus. Predicted xeno-miRNA data were collected from the study by
Shu et al.
The xeno-miRNA targets were predicted base on two algorithms with default parameters
- miRanda (score >= 140)
and TarPmiR
(probability >= 0.5).
